BDBM50502541 Elafibranor::GFT-505::Gft505

SMILES CSc1ccc(cc1)C(=O)\C=C\c1cc(C)c(OC(C)(C)C(O)=O)c(C)c1

InChI Key InChIKey=AFLFKFHDSCQHOL-IZZDOVSWSA-N

Data  1 IC50  16 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50502541   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  2.12E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
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TargetPeroxisome proliferator-activated receptor gamma(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  175nMAssay Description:Agonist activity at PPARgamma (unknown origin) assessed as transcriptional activationMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails PubMed
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TargetPeroxisome proliferator-activated receptor delta(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  115nMAssay Description:Agonist activity at PPARbeta (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  10nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
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TargetPeroxisome proliferator-activated receptor delta(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  10nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Guangzhou Medical University

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataIC50:  3.96E+4nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISAMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  375nMAssay Description:Agonist activity at human PPARalpha transfected in human HepG2 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor gamma(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  3.96E+3nMAssay Description:Agonist activity at human PPARgamma transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor delta(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  249nMAssay Description:Agonist activity at human PPARdelta transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  760nMAssay Description:Agonist activity at human Gal4 fused PPARalpha LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor delta(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  730nMAssay Description:Agonist activity at human Gal4 fused PPARdelta LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor gamma(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  2.79E+3nMAssay Description:Agonist activity at human Gal4 fused PPARgamma LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  820nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor delta(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  843nMAssay Description:Agonist activity at PPARdelta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor gamma(Human)
Wuxi Apptec (Shanghai) Co.

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  1.84E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  45nMAssay Description:Agonist activity at PPARalpha (unknown origin) assessed as transcriptional activationMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails PubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL

TargetPeroxisome proliferator-activated receptor alpha(Human)
Terns Pharmaceuticals

Curated by ChEMBL

LigandBDBM50502541(Elafibranor | GFT-505 | Gft505)Copy SMILESCopy InChI

Affinity DataEC50:  225nMAssay Description:Agonist activity at PPARalpha (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
PC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL