BDBM50514432 CHEMBL4438385
SMILES Cl.Cl.COC(=O)Nc1ccc-2c(NC(=O)[C@H](C)CCC[C@H](NC(=O)c3ncn(c3C)-c3cccc(Cl)c3F)c3cc-2ccn3)c1
InChI Key InChIKey=GRFBPSQUHXGFOO-VQRJTFEDSA-N
Data 12 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50514432
Affinity DataKi: 4.10nMAssay Description:Inhibition of human activated factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Inhibition of human kallikrein using H-(D)-Pro-Phe-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 2.53E+3nMAssay Description:Inhibition of activated human coagulation factor XII using H-(D)-CHT-Gly-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 2.94E+3nMAssay Description:Inhibition of activated human tPA using methylsulfonyl-D-cyclohexylalanyl-Gly-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human trypsin using N-benzoyl-Ile-Glu-OH-OMe-Gly-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.15E+4nMAssay Description:Inhibition of human alpha-thrombin using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.33E+4nMAssay Description:Inhibition of activated human coagulation factor VII using H-(D)-Ile-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.33E+4nMAssay Description:Inhibition of activated human coagulation factor X using N-benzoyl-Ile-Glu-OH-OMe-Gly-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human plasmin using H-(D)-Val-Leu-Lys-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataKi: >1.51E+4nMAssay Description:Inhibition of activated human urokinase using pyro-Glu-Gly-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >2.15E+4nMAssay Description:Inhibition of activated human protein C using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: >2.71E+4nMAssay Description:Inhibition of activated human coagulation factor IX using 7-amino-4-methylcoumarin as substrate by spectrofluorimetryMore data for this Ligand-Target Pair