BDBM50517807 CHEMBL4570374

SMILES Brc1cc(NCc2cccc3nonc23)c2cn[nH]c2c1

InChI Key InChIKey=PEQNQOXHKPQOQM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50517807   

TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50:  2.94E+3nMAssay Description:Inhibition of human TDO expressed in Escherichia coli at using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50:  740nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine level after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50:  7.54E+3nMAssay Description:Inhibition of human TDO expressed in human A172 assessed as reduction in kynurenine formation using L-tryptophan as substrate after 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed