BDBM50527021 Lmb763::Nidufexor

SMILES Cn1nc(C(=O)N(Cc2ccccc2)Cc2ccc(cc2)C(O)=O)c2COc3ccc(Cl)cc3-c12

InChI Key InChIKey=JYTIXGYXBIBOMN-UHFFFAOYSA-N

Data  14 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50527021   

TargetProgesterone receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at Progesterone receptor (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at ERalpha (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >8.00E+4nMAssay Description:Agonist activity at human GPBAR1 expressed in Jurkat cells assessed as increase in intracellular cAMP level incubated for 1 hr by fluorescence based ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at Glucocorticoid receptor (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PXR (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused RXR LBD (unknown origin) expressed in HEK293T cells incubated for 24 by BrightGlo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused PPARgamma (unknown origin) expressed in HEK293T cells incubated for 24 by BrightGlo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused ERalpha (unknown origin) expressed in HEK293T cells incubated for 24 by BrightGlo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at androgen receptor (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50:  7nMAssay Description:Agonist activity at GST-tagged human FXR-LBD (193 to 472 residues) using biotinylated SRC-1 peptide as substrate incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50:  32nMAssay Description:Agonist activity at FXR transfected in human HEK293T cells o-expressing pGL3/hBSEP/luc incubated for 24 hrs by Steady-Glo reagent based luciferase re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused LXR LBD (unknown origin) expressed in HEK293T cells incubated for 24 by BrightGlo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PPARgamma (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Human)
Genomics Institute of The Novartis Research Foundation (Gnf)

Curated by ChEMBL
LigandPNGBDBM50527021(Lmb763 | Nidufexor)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at GAL4-fused Glucocorticoid receptor (unknown origin) expressed in HEK293T cells incubated for 24 by BrightGlo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed