BDBM50532593 ZD-4054::ZD4054::Zibotentan

SMILES Cc1cnc(c(n1)OC)NS(=O)(=O)c2cccnc2c3ccc(cc3)c4nnco4

InChI Key InChIKey=FJHHZXWJVIEFGJ-UHFFFAOYSA-N

Data  1 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50532593   

TargetEndothelin-1 receptor(Human)
The Second Affiliated Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532593BDBM50532593(ZD-4054 | ZD4054 | Zibotentan)
Affinity DataKi:  13nMAssay Description:Inhibition of VEGFR2 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEndothelin-1 receptor(Human)
The Second Affiliated Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532593BDBM50532593(ZD-4054 | ZD4054 | Zibotentan)
Affinity DataIC50: 21nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelin-1 receptor(Human)
The Second Affiliated Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532593BDBM50532593(ZD-4054 | ZD4054 | Zibotentan)
Affinity DataIC50: 21nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532593BDBM50532593(ZD-4054 | ZD4054 | Zibotentan)
Affinity DataIC50: 100nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532593BDBM50532593(ZD-4054 | ZD4054 | Zibotentan)
Affinity DataIC50: 100nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed