BDBM50533254 CHEMBL4550207

SMILES CNC(=O)[C@@H]1C[C@@H](CN1C(=O)c1ccc(CN)c(OC)c1)N1CCc2c(C1)cccc2OCCOC

InChI Key InChIKey=OBAPCSRNRUUGDW-GMAHTHKFSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50533254   

TargetChymotrypsinogen B2(Homo sapiens)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Homo sapiens)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50:  8nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50:  8nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533254(CHEMBL4550207)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed