BDBM50536681 CHEMBL4552628

SMILES Cc1sc(cc1-c1cnn2cc(Cl)cnc12)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F

InChI Key InChIKey=NGFGTMFVWSDFPS-UHFFFAOYSA-N

Data  100 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 100 hits for monomerid = 50536681   

LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length recombinant human GST-tagged MARK3 expressed in baculovirus expression system using biotinylated-Cdc25C peptide substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length recombinant human His-tagged CDK7 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length recombinant human GST-tagged TBK1 expressed in insect cells by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length recombinant human His-tagged STK22D expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDeath-associated protein kinase 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human GST-tagged DAPK1 catalytic domain expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 47nMAssay Description:Inhibition of full-length recombinant human His-tagged RPS6KA3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length recombinant human GST-tagged IKK-epsilon expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 51nMAssay Description:Inhibition of full-length recombinant human His-tagged CDK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 53nMAssay Description:Inhibition of full-length recombinant human GST and His-tagged AMPK alpha1/beta1/gamma1 expressed in baculovirus expression system by LanthaScreen as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 61nMAssay Description:Inhibition of full-length recombinant human GST and His-tagged CDK5/P25 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 110nMAssay Description:Inhibition of full-length human GST-tagged GSK3A expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 130nMAssay Description:Inhibition of full-length recombinant human GST-tagged DYRK1A expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMisshapen-like kinase 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human His-tagged MINK1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 150nMAssay Description:Inhibition of full-length recombinant human His-tagged GSK3B expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 13(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 160nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPK13 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 170nMAssay Description:Inhibition of full-length recombinant human GST-tagged MST4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 200nMAssay Description:Inhibition of full-length recombinant human His-tagged NUAK1 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 200nMAssay Description:Inhibition of full-length recombinant human His-tagged CHEK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 240nMAssay Description:Inhibition of full-length recombinant human His-tagged CDK9/cyclin T1 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 280nMAssay Description:Inhibition of MARK4 in mouse cortical neurons assessed as inhibition of okadaic acid-induced tau phosphorylation at S262 residue preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 330nMAssay Description:Inhibition of full-length recombinant human His-tagged PDK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 390nMAssay Description:Inhibition of full-length recombinant human His-tagged CHEK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek4(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 480nMAssay Description:Inhibition of full-length recombinant human GST-tagged NEK4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 580nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic FLT3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 670nMAssay Description:Inhibition of full-length recombinant human GST-tagged GRK4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProtein kinase C iota type(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 720nMAssay Description:Inhibition of full-length recombinant human His-tagged PRKCI expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant human GST-tagged SGK catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 870nMAssay Description:Inhibition of full-length recombinant human His-tagged AKT1-alpha expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 950nMAssay Description:Inhibition of recombinant human GST-tagged RAF1 Y340D/Y341D mutant expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged CDC42BPA catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAP2K1 expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full-length recombinant human PRKCZ expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged BRAF expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROCK2 (1 to 552 residues) catalytic domain expressed in baculovirus expression system by Z'-LYT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged MAPK1 expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K8 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic NTRK3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged PASK catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged RPS6KB1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged PIM1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 6(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged GRK6 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human GST-tagged IRAK1 (194 to 712 residues) catalytic domain expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged PAK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic NTRK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged ROCK1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged AKT3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536681(CHEMBL4552628)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged AKT2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
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