BDBM50536834 CHEMBL4590201
SMILES FCC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1
InChI Key InChIKey=YGHHDWRITNGHCH-KRWDZBQOSA-N
Data 19 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50536834
TargetCysteine protease ATG4B(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assayMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP9 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ACE (unknown origin) using Mca-RPPGFSAFK (Dnp) as substrate preincubated for 20 mins followed by substrate addition by fluorescence pla...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of cathepsin G (unknown origin) using Suc-AAPF-pNA as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase3 (unknown origin) using Ac-DMQD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
TargetTryptase beta-2(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of tryptase beta2 (unknown origin) using Z-GPR-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase7 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant human cathepsin B (332 residues) expressed in CHO cells using Z-FR-AMC as substrate preincubated for 20 mins followed by su...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP3 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
TargetCysteine protease ATG4B(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase2 (unknown origin) using ICH-1 as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human cathepsin D (400 residues) expressed in CHO cells using 5-FAM/QXL 520 FRET peptide as substrate preincubated for 20 m...More data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of neutrophil elastase (unknown origin) using MeOSu-AAPV-AMC as substrate preincubated for 20 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase8 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of caspase9 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
TargetCalpain-1/Calpain-2 catalytic subunit(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of calpain (unknown origin) using calpain substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader a...More data for this Ligand-Target Pair
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ECE1 (unknown origin) using Mca-RPPGFSAFK (Dnp) as substrate preincubated for 20 mins followed by substrate addition by fluorescence pl...More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP1 (unknown origin) using Mca-PLGL-Dpa-AR as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate ...More data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 20S proteasome (unknown origin) using suc-LLVY-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence...More data for this Ligand-Target Pair