BDBM50543916 CHEMBL4639407

SMILES COc1c(ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1Cc2cn(nc2C1)-c1ccc(F)cn1)C#N

InChI Key InChIKey=XJOGEHPRWJSAKP-LBPRGKRZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50543916   

TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50543916(CHEMBL4639407)
Affinity DataIC50:  26nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50543916(CHEMBL4639407)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by electrophysiology QPatch assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50543916(CHEMBL4639407)
Affinity DataIC50:  21nMAssay Description:Inhibition of human GlyT1 expressed in human HEK cells assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed