BDBM50544851 CHEMBL4647611::US11292781, Compound T29

SMILES [H][C@]12CCc3c(nc(nc3[C@]1(C)C=C(C#N)C(=O)[C@@H]2C)-c1ccncc1)-c1ccncc1

InChI Key InChIKey=BMMMKLNFEJZQHB-LVJZWUNYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544851   

TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544851(CHEMBL4647611 | US11292781, Compound T29)
Affinity DataIC50:  254nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544851(CHEMBL4647611 | US11292781, Compound T29)
Affinity DataIC50:  337nMAssay Description:The RORγ assay system was purchased from Indigo Biosciences. This nuclear receptor assay utilizes a human cell line that has been engineered to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetNuclear receptor ROR-gamma(Human)
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544851(CHEMBL4647611 | US11292781, Compound T29)
Affinity DataIC50:  128nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed