BDBM50553658 CHEMBL4790915

SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(on4)C(C)(C)C)cc3F)c2cc1OC

InChI Key InChIKey=UMVARAZJYYZKEH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50553658   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50553658(CHEMBL4790915)
Affinity DataIC50:  0.0720nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50553658(CHEMBL4790915)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of FLT3 ITD/F691L double mutant (unknown origin) expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50553658(CHEMBL4790915)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of FLT3 ITD/D835Y double mutant (unknown origin) expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed