BDBM50556315 CHEMBL4745330

SMILES COc1cccc2nc(Nc3cccc(NC(=O)c4ccc(N5CCN(C)CC5)c(c4)C(F)(F)F)c3)ccc12

InChI Key InChIKey=XCHCIVYQULUSFP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50556315   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50556315(CHEMBL4745330)
Affinity DataIC50:  370nMAssay Description:Inhibition of human CRAF using MEK1 (K97R) as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50556315(CHEMBL4745330)
Affinity DataIC50:  2.25E+3nMAssay Description:Inhibition of human DDR1 using KKSRGDYMTMQIG as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50556315(CHEMBL4745330)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of human BRAF V600E mutant using MEK1 (K97R) as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50556315(CHEMBL4745330)
Affinity DataIC50:  2.94E+3nMAssay Description:Inhibition of human BRAF using MEK1 (K97R) as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50556315(CHEMBL4745330)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human TRKA using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed