BDBM50579725 CHEMBL5072324

SMILES c1ccc2c(c1)CCN2C(=O)CCC(=O)OCC(F)F

InChI Key InChIKey=ZBGADGOMZKMKIY-UHFFFAOYSA-N

Data  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579725   

TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50579725(CHEMBL5072324)
Affinity DataIC50: 12nMAssay Description:Covalent inhibition of glycosylated Notum 1 (unknown origin) using OPTS as reporter substrate incubated for 40 mins by microplate reader based analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50579725(CHEMBL5072324)
Affinity DataEC50:  300nMAssay Description:Inhibition of Notum 1 (unknown origin) expressed in HEK293 cells harbouring TCF/LEF luciferase reporter gene assessed as modulation of Wnt/beta-caten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)