BDBM50586222 CHEMBL5082786

SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccnc3C)n(Cc3ccco3)c(=O)c21

InChI Key InChIKey=PQYXGDZAWKQEEM-UHFFFAOYSA-N

Data  6 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50586222   

TargetBromodomain-containing protein 4(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetBromodomain-containing protein 4(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50:  130nMAssay Description:Inhibition of BRD4-BD2 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50:  20nMAssay Description:Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataKd:  150nMAssay Description:Inhibition of BRD3-BD2 (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of BRD3-BD1 domain (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetBromodomain-containing protein 2(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of BRD2-BD1 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetBromodomain-containing protein 2(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50:  71nMAssay Description:Inhibition of BRD2-BD2 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)