BDBM50590873 CHEMBL5176684

SMILES FC(F)(F)COc1ccc(CN2CCN(CC2)C(=O)c2ccc(cc2)-c2noc(n2)-c2ccc(cc2)C(F)(F)F)cc1

InChI Key InChIKey=DXKRDEGPUVHRJG-UHFFFAOYSA-N

Data  13 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50590873   

TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataKd:  114nMAssay Description:Binding affinity to human STAT3-SH2 domain (127 to 722 residues) assessed as dissociation constant by MST assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 8(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 13(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p38delta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 1A2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50:  2.29E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50:  1.59E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2D6(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataKd:  76nMAssay Description:Binding affinity to human STAT3 (127 to 722 residues) assessed as dissociation constant by MST assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed