BDBM50602308 CHEMBL5192172

SMILES NC(=O)[C@@H]1CCCN1c1ccc2-c3nc(cn3CCOc2c1)N1CC[C@H](O)C1=O

InChI Key InChIKey=RCEHXDMYLSWDOT-GJZGRUSLSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50602308   

LigandPNGBDBM50602308(CHEMBL5192172)
Affinity DataKi:  0.355nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602308(CHEMBL5192172)
Affinity DataEC50:  327nMAssay Description:Inhibition of PI3Kalpha in human HDQ-P1 cells assessed as reduction in PRAS40 phosphorylation after 24 hrs by electrochemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602308(CHEMBL5192172)
Affinity DataEC50:  63nMAssay Description:Inhibition of PI3Kalpha H1047R mutant in human HCC1954 cells assessed as reduction in PRAS40 phosphorylation after 24 hrs by electrochemiluminescent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed