BDBM50610353 CHEMBL5270898

SMILES Cc1cc(nc(n1)N1CCCC1)N1CCN(CC1)C(=O)c1ccc(cc1)C(C)(C)C

InChI Key InChIKey=QJZSBJRVAIZDFO-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50610353   

TargetLysosomal acid glucosylceramidase(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50610353(CHEMBL5270898)
Affinity DataEC50:  9.60nMAssay Description:Chaperone activity at GCase N370S GBA mutant in patient derived fibroblast cell using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate assess...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysosomal acid glucosylceramidase(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50610353(CHEMBL5270898)
Affinity DataIC50:  27nMAssay Description:Inhibition of GCase in patient derived fibroblast cells using 5'pentafluorobenzoylaminofluorescein-di-beta-D-glucoside as substrate assessed as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysosomal acid glucosylceramidase(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50610353(CHEMBL5270898)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of recombinant GCase (unknown origin) using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate at pH 4.5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysosomal acid glucosylceramidase(Human)
Eisai

Curated by ChEMBL
LigandPNGBDBM50610353(CHEMBL5270898)
Affinity DataEC50:  13nMAssay Description:Chaperone activity at GCase N370S GBA mutant in patient derived fibroblast cell assessed as GCase level incubated for 5 days by immunocytochemistry a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed