BDBM510865 1-(difluoromethyl)- 6-(2-hydroxy-2- methylpropoxy)-N- [(aR)-6-[(4-carbamoyl-1- phenyl-1H-pyrazol-3- yl)oxy]spiro[3.3] heptan-2-yl]-1H- indazole-3- carboxamide::US11078197, Example 42::US11673886, Example 42

SMILES CC(C)(O)COc1ccc2c(nn(C(F)F)c2c1)C(=O)N[C@H]1C[C@]2(C1)C[C@@H](C2)Oc1nn(cc1C(N)=O)-c1ccccc1

InChI Key InChIKey=TVVZCSKROKCEHQ-FSKXATTISA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510865   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510865(1-(difluoromethyl)- 6-(2-hydroxy-2- methylpropoxy)...)
Affinity DataIC50:  13.7nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510865(1-(difluoromethyl)- 6-(2-hydroxy-2- methylpropoxy)...)
Affinity DataIC50:  1.37E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent