BDBM510924 6-fluoro-N-[(aR)-6- ({5-carbamoyl-1- methyl-1H- pyrazolo[3,4- b]pyridin-6- yl}oxy)spiro[3.3] heptan-2-yl]quinoline- 3-carboxamide::US11078197, Example 103::US11673886, Example 103

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cnc5ccc(F)cc5c4)C3)nc12

InChI Key InChIKey=CMJDHSYRDWEFNM-RPPIVITFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510924   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510924(6-fluoro-N-[(aR)-6- ({5-carbamoyl-1- methyl-1H- py...)
Affinity DataIC50:  5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510924(6-fluoro-N-[(aR)-6- ({5-carbamoyl-1- methyl-1H- py...)
Affinity DataIC50:  5.00E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent