BDBM511526 4-sulfamoylbenzoic acid (CAS- RN 138-41-0)::US11059794, Example 4.02

SMILES Cc1nnn(n1)Cc2cc(ccc2CCC(=O)N3CCN(CC3)C(=O)c4ccc(cc4)S(=O)(=O)N)C(F)(F)F

InChI Key InChIKey=UTICIZWBNOHDIF-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511526   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 511526BDBM511526(4-sulfamoylbenzoic acid (CAS- RN 138-41-0) | US110...)
Affinity DataIC50: 13nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 511526BDBM511526(4-sulfamoylbenzoic acid (CAS- RN 138-41-0) | US110...)
Affinity DataIC50: 34.3nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent