BDBM516995 (R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)amino)-1H- pyrazolo[3,4-b]pyridin- 4-yl)oxy)phenyl)-2,5- dioxo-1-phenyl- 1,2,5,6,7,8- hexahydroquinoline-3- carboxamide::US11104676, Example 65

SMILES C[C@H](CO)Nc1n[nH]c2nccc(Oc3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccccc5)c4=O)cc3F)c12

InChI Key

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 516995   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  1.00E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  5.40E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  6.56E+4nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  3.5nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [1-13,15-1390](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  4.60nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230S](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  4.80nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [D1228N](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  10.1nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [F1200I](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  5nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [L1195V](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  195nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230C](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  3.60nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230H](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  10.1nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [D1228H](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM516995((R)-N-(3-fluoro-4-((3- ((1-hydroxxypropan-2- yl)am...)
Affinity DataIC50:  16.3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent