BDBM525755 US11174252, Compound 442

SMILES CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(C)CC2)ncc1F

InChI Key InChIKey=YZSCPLGKKMSBMV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 525755   

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  2nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  1nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  73nMAssay Description:CDK1 (cyclin B): IC50 values of compounds against CDK1 (cyclin B) were determined by Z′-LYTE™. These screening assays were performed at In...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  7nMAssay Description:CDK5 (p25): IC50 values of compounds against CDK5 (p25) were determined by Z′-LYTE™. These screening assays were performed at Invitrogen L...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50: >5.00E+4nMAssay Description:PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  1.16E+3nMAssay Description:CDK7 (cyclin H): IC50 values of compounds against CDK7 (cyclin H) were determined by Adapta™ Assay at Invitrogen Life Technologies (Grand Island...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCyclin-K/Cyclin-dependent kinase 9(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  41nMAssay Description:CDK9 (cyclin K): IC50 values of compounds against CDK9 (cyclin K) were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen Life Te...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  353nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Nuvation Bio

US Patent
LigandPNGBDBM525755(US11174252, Compound 442)
Affinity DataIC50:  27nMAssay Description:CDK5 (p25): IC50 values of compounds against CDK5 (p25) were determined by Z′-LYTE™. These screening assays were performed at Invitrogen L...More data for this Ligand-Target Pair
In DepthDetails US Patent