BDBM544069 (M)-2-[6- Chloro-4- [(2S,5R)-2,5- dimethyl-4- prop-2-enoyl- piperazin-1-yl]- 1-(2-isopropyl- 4-methyl-3- pyridyl)-2-oxo- pyrido[2,3- d]pyrimidin-7- yl]-3-fluoro- benzamide::US11285156, Ex.# 92-24

SMILES CC(C)c1nccc(C)c1-n1c2nc(c(Cl)cc2c(nc1=O)N1C[C@@H](C)N(C[C@@H]1C)C(=O)C=C)-c1c(F)cccc1C(N)=O

InChI Key InChIKey=LYOKGHIEPAZDSV-MOPGFXCFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544069   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544069((M)-2-[6- Chloro-4- [(2S,5R)-2,5- dimethyl-4- prop...)
Affinity DataIC50:  19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent