BDBM551365 8-chloro-1-[(3R)-1-methylpyrrolidin-3-yl]-2-[(4- methyl-1H-1,2,3-triazol-1-yl)methyl]-1H- imidazo[4,5-c]quinoline::US11312713, Example 62

SMILES CN1CC[C@H](C1)n1c(Cn2cc(C)nn2)nc2cnc3ccc(Cl)cc3c12

InChI Key InChIKey=KYZSJHQQVQXDRZ-CQSZACIVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 551365   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM551365(8-chloro-1-[(3R)-1-methylpyrrolidin-3-yl]-2-[(4- m...)
Affinity DataIC50:  6.5nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM551365(8-chloro-1-[(3R)-1-methylpyrrolidin-3-yl]-2-[(4- m...)
Affinity DataIC50:  5.78nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent