BDBM589158 US11548900, Example 129

SMILES CN(C\C=C\C(=O)N1CCOc2c1ccc1ncnc(Nc3ccc(Oc4ccn5ncnc5c4)c(Cl)c3)c21)C1CCC1

InChI Key InChIKey=JWSPAXKLFBECIB-ZZXKWVIFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 589158   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM589158(US11548900, Example 129)
Affinity DataIC50:  275nMAssay Description:The assay for the inhibition of EGFR and HER2 kinase activity by small molecular compounds was carried out using the method as follows:1) Dilution of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM589158(US11548900, Example 129)
Affinity DataIC50: <50nMAssay Description:The assay for the inhibition of EGFR and HER2 kinase activity by small molecular compounds was carried out using the method as follows:1) Dilution of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent