BDBM591869 US11566007, Example A549

SMILES CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3cccc(c3)-c3ccc1c2c3)NC(=O)[C@H](C(C)C)N1CC[C@@]2(CCN(C2)C(=O)C#C[C@@H]2COCCN2C)C1=O)-c1cccnc1[C@H](C)OC

InChI Key InChIKey=MWHJAHJNBCRHKM-QXRITPGDSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 591869   

TargetGTPase KRas [G12C](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50: <10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas(Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G13C](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  550nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G13D](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [Q61H](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  550nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50: >1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas [G12C](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12S](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas(Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas [Q61R](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase NRas [Q61K](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12V](Homo sapiens (Human))
Revolution Medicines

US Patent
LigandPNGBDBM591869(US11566007, Example A549)
Affinity DataIC50:  5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent