BDBM605443 N-(2-chloro-5-(3-cyano-4-((1S- phenylethyl)amino)quinolin-6-yl)pyridin- 3-yl)methanesulfonamide::US11673876, Compound 48S

SMILES C[C@H](Nc1c(cnc2ccc(cc12)-c1cnc(Cl)c(NS(C)(=O)=O)c1)C#N)c1ccccc1

InChI Key InChIKey=RQUAEMCWWIFVCJ-HNNXBMFYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605443   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605443(N-(2-chloro-5-(3-cyano-4-((1S- phenylethyl)amino)q...)
Affinity DataIC50: <2nMAssay Description:Z′-LYTEŽ Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605443(N-(2-chloro-5-(3-cyano-4-((1S- phenylethyl)amino)q...)
Affinity DataIC50: <2nMAssay Description:Z′-LYTEŽ Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mekanistic Therapeutics

US Patent
LigandPNGBDBM605443(N-(2-chloro-5-(3-cyano-4-((1S- phenylethyl)amino)q...)
Affinity DataIC50: >200nMAssay Description:Z′-LYTEŽ Assay Conditions: Test Compounds: The Test Compounds are screened in 1% DMSO (final) in the well. For 10 point titrations, 3-fold seri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent