BDBM619956 6-(2-((3S,8aS)-7-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-5-oxo-1,2,3,5,8,8a-hexahydroindolizin-3-yl)-1H-imidazol-5-yl)-3,4-dihydroquinolin-2(1H)-one::US20230295157, Example 280

SMILES O=C1CCc2cc(-c3cnc([C@@H]4CC[C@H]5CC(c6c(-n7cnnn7)ccc(Cl)c6F)=CC(=O)N54)[nH]3)ccc2N1

InChI Key InChIKey=XZCGLEWKUHGGKA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619956   

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619956BDBM619956(US20230295157, Example 280 | 6-(2-((3S,8aS)-7-(3-C...)
Affinity DataIC50: 0.600nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619956BDBM619956(US20230295157, Example 280 | 6-(2-((3S,8aS)-7-(3-C...)
Affinity DataIC50: 1.20nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent