BDBM625351 US20230322769, Compound 64::US20230322769, Compound 69::US20230322769, Compound 70
SMILES COc1ccc(CN2CCCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cc3CCCn3n2)cn1
InChI Key InChIKey=XIHXBNRAWIZORJ-UHFFFAOYSA-N
Data 16 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 625351
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 1.17nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 754nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 1.62nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 1.02nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 23.9nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 4.74E+3nMAssay Description:Inhibition of hERG Potassium Channel by Prepared Compounds The final concentrations of test compounds were all prepared on the day of experiment and ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 26.6nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 111nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 42.8nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 30.7nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 387nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 18.6nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 38.5nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 22.3nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 12nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 1.01nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair