BDBM645624 US20240018138, Compound 102

SMILES C[C@H]1c2c3ccc(c(c3[nH]c2CCN1C(=O)COC)Cl)Cl

InChI Key InChIKey=DWCKYKBOPOOIPJ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 645624   

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 645624BDBM645624(US20240018138, Compound 102)
Affinity DataIC50: 27nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 645624BDBM645624(US20240018138, Compound 102)
Affinity DataIC50: 27.2nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Dev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 645624BDBM645624(US20240018138, Compound 102)
Affinity DataIC50: 450nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)