BDBM65454 191732-72-6::CC-5013::Lenalidomide::Revimid::Revlimid::US11530219, Compound Lenalidomide::US20250129088, Compound Lenalidomide::US20250215012, Example Lenalidomide::US20250243210, Compound Lena-NH2::US20250268906, Compound lenalidomide::US9694015, 6.1

SMILES Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O

InChI Key InChIKey=GOTYRUGSSMKFNF-UHFFFAOYSA-N

Data  6 KI  26 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 65454   

TargetZinc finger protein Aiolos(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataEC50:  70nMAssay Description:Induction of ePL tagged Aiolos degradation in human DF15 cells incubated for 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 89nMAssay Description:Inhibition of CRBN (unknown origin) measured after 60 mins incubation by BMG readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKd:  100nMAssay Description:CRBN affinity experiments were performed to evaluate the binding affinity of AST-DT-135, AST-DT-218, and AST-DT-220 to CRBN proteins. First, CRBN pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2025
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKd:  178nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as dissociation constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMediator of DNA damage checkpoint protein 1(Human)
Celgene

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 190nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Celgene

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 220nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Celgene

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 390nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 390nMAssay Description:Displacement of fluorescent tracer from NanoLuc-tagged CRBN (unknown origin) by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetZinc finger protein Helios(Human)
University of Michigan

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 550nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2025
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKi:  800nMAssay Description:Binding affinity to GST-tagged wild-type human CRBN incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetInterleukin-6(Human)
Celgene

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.20E+3nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKi:  1.49E+3nMAssay Description:Binding affinity to CBRN (unknown origin) incubated for 60 mins by lenalidomide displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKi:  1.49E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent

LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.50E+3nMpH: 7.0Assay Description:The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 2.00E+3nMAssay Description:To measure compound binding to endogenous CRBN.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 2.25E+3nMAssay Description:The specific methods are as follows:1. According to the instructions of the CEREBLON BINDING kits, the compounds of the present invention to be teste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2025
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 2.38E+3nMAssay Description:1. According to the instructions of the CEREBLON BINDING kits, the compounds to be tested of the present invention and lenalidomide were serially dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2025
Entry Details
Go to US Patent

LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 3.00E+3nMpH: 8.0 T: 2°CAssay Description:Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 3.10E+3nMAssay Description:The detection is based on homogeneous time-resolved fluorescence (HTRF) technology. When the donor and the acceptor are close, the donor can transfer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2025
Entry Details
Go to US Patent

TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 3.60E+3nMAssay Description:Binding affinity to GST-tagged wild type human CRBN incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 5.19E+3nMAssay Description:Inhibition of BRD4 bromodomain 2 (unknown origin) in HEK293 cells cotransfected with eGFP by flow cytometry based mCherry reporter gene analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 5.19E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKi:  6.40E+3nMAssay Description:Binding affinity to human CRBN TBD assessed as inhibition constant using BODIPY-uracil as substrate by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetGlyceraldehyde-3-phosphate dehydrogenase, cytosolic(Leishmania mexicana)
Celgene

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetC-C motif chemokine 3(Human)
Celgene

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetC-C motif chemokine 4(Human)
Celgene

US Patent
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2018
Entry Details
Go to US Patent

TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataKi:  1.63E+4nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.90E+4nMAssay Description:Binding affinity to human CRBN TBD using BODIPY-uracil as substrate by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 3.78E+4nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed