BDBM65497 CC-220 (Compound 6)::US9694015, 6.4S
SMILES O=C1N(Cc2c1cccc2OCc1ccc(CN2CCOCC2)cc1)[C@H]1CCC(=O)NC1=O
InChI Key InChIKey=IXZOHGPZAQLIBH-NRFANRHFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 65497
TargetProtein cereblon(Homo sapiens (Human))
Max Planck Institute For Developmental Biology
Curated by ChEMBL
Max Planck Institute For Developmental Biology
Curated by ChEMBL
Affinity DataKi: 4.94E+3nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 3.80nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
TargetProtein cereblon(Homo sapiens (Human))
Max Planck Institute For Developmental Biology
Curated by ChEMBL
Max Planck Institute For Developmental Biology
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMpH: 7.0Assay Description:The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair