BDBM6863 US8815926, 101::US8815926, 295

SMILES COc1ncc(-c2nc3C(=O)N(C(c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)cn(C)c2=O)c(OC)n1

InChI Key InChIKey=AGBSXNCBIWWLHD-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6863   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50:  0.318nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50:  0.340nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
TargetProtein Mdm4(Homo sapiens (Human))TBA
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50:  0.210nMAssay Description:Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryMore data for this Ligand-Target Pair
In DepthDetails
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50:  0.210nMAssay Description:Tested for inhibitory activity against (DPDE)delta receptor in mouse vas deferensMore data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetProtein Mdm4(Homo sapiens (Human))TBA
LigandPNGBDBM6863(US8815926, 101 | US8815926, 295)
Affinity DataIC50:  3.00E+3nMAssay Description:Tested for its antagonist activity against kappa receptor using U-69,593 as radioligand in isolated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails