BDBM704661 5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide and 5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[5-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide::US20240374606, Example 214

SMILES Cc1c(cn(n1)CC(F)(F)F)Nc2c(nc(c(n2)C3CC3)c4cncc5c4ncn5C)C(=O)N

InChI Key InChIKey=YLGMPWWMPCGYBF-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 704661   

LigandChemical structure of BindingDB Monomer ID 704661BDBM704661(5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-y...)
Affinity DataIC50: 4nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 704661BDBM704661(5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-y...)
Affinity DataIC50: 175nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 704661BDBM704661(5-Cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-y...)
Affinity DataIC50: 2.25E+3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent