BDBM747241 (S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)(5-(2- hydroxyethoxy)pyrimidin-2-yl)methanone::US20250179079, Compound 77B

SMILES C[C@H]1c2c([nH]c3c(Cl)c(Cl)ccc23)CCN1C(=O)c1ncc(OCCO)cn1

InChI Key InChIKey=AIKATVNPTUCXJK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 747241   

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747241BDBM747241((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 32nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747241BDBM747241((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 32nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics U.S.

US Patent
LigandChemical structure of BindingDB Monomer ID 747241BDBM747241((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 60nMAssay Description:Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)