BDBM81467 CAS_569-65-3::CHEMBL1085765::Meclizine::NSC_4034::US9182402, 13

SMILES Cc1cccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)c1

InChI Key InChIKey=OCJYIGYOJCODJL-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 81467   

TargetHistamine H1 receptor(RAT)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM81467(CAS_569-65-3 | CHEMBL1085765 | Meclizine | NSC_403...)
Affinity DataKi:  250nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM81467(CAS_569-65-3 | CHEMBL1085765 | Meclizine | NSC_403...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in presence of 0.01% Triton X-100More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM81467(CAS_569-65-3 | CHEMBL1085765 | Meclizine | NSC_403...)
Affinity DataIC50: >2.00E+4nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCruzipain(Trypanosoma cruzi)
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM81467(CAS_569-65-3 | CHEMBL1085765 | Meclizine | NSC_403...)
Affinity DataIC50:  1.29E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM81467(CAS_569-65-3 | CHEMBL1085765 | Meclizine | NSC_403...)
Affinity DataIC50:  2.02E+3nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTrypsin(Sus scrofa)
Fred Hutchinson Cancer Research Center

US Patent
LigandPNGBDBM81467(CAS_569-65-3 | CHEMBL1085765 | Meclizine | NSC_403...)
Affinity DataIC50: >2.00E+4nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In DepthDetails US Patent