Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with Target = '7-dehydrocholesterol reductase'
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407454BDBM50407454(CHEMBL5281526)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20607BDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKd:  1nMAssay Description:Binding affinity towards antiestrogen binding site AEBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396754BDBM50396754(CHEMBL2172347)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50406621BDBM50406621(CHEMBL9820)
Affinity DataKi:  4nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human DHCR7 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50406617BDBM50406617(CHEMBL276388)
Affinity DataKi:  7nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50406618BDBM50406618(CHEMBL9875)
Affinity DataKi:  12nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  14nMAssay Description:Binding affinity to human DHCR7 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411320BDBM50411320(CHEMBL222694)
Affinity DataIC50: 30nMAssay Description:Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407452BDBM50407452(CHEMBL5284923)
Affinity DataIC50: 30nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411320BDBM50411320(CHEMBL222694)
Affinity DataIC50: 30nMAssay Description:Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50406620BDBM50406620(CHEMBL9864)
Affinity DataKi:  33nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411320BDBM50411320(CHEMBL222694)
Affinity DataIC50: 40nMAssay Description:Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50406616BDBM50406616(CHEMBL268041)
Affinity DataKi:  48nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411319BDBM50411319(CHEMBL266892)
Affinity DataIC50: 50nMAssay Description:Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411320BDBM50411320(CHEMBL222694)
Affinity DataIC50: 60nMAssay Description:Growth inhibition of multidrug resistant MCF7/Adr cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411319BDBM50411319(CHEMBL266892)
Affinity DataIC50: 70nMAssay Description:Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411319BDBM50411319(CHEMBL266892)
Affinity DataIC50: 80nMAssay Description:Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396753BDBM50396753(CHEMBL2172349)
Affinity DataIC50: 120nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 150nMAssay Description:Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 200nMAssay Description:Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 300nMAssay Description:Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412080BDBM50412080(CHEMBL342394)
Affinity DataIC50: 400nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170646BDBM50170646(CHEMBL2172263 | CHEMBL189871 | 4-(2-{4-[(E)-3-(4-C...)
Affinity DataIC50: 500nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412082BDBM50412082(CHEMBL455316)
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412077BDBM50412077((+)-PACHYSAMINE B)
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407449BDBM50407449(CHEMBL5285995)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407448BDBM50407448(CHEMBL4454956)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50411319BDBM50411319(CHEMBL266892)
Affinity DataIC50: 2.00E+3nMAssay Description:Growth inhibition of multidrug resistant MCF7/Adr cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50406619BDBM50406619(CHEMBL9808)
Affinity DataKi:  2.00E+3nMAssay Description:Compound was tested for the inhibition of delta24-sterol reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407451BDBM50407451(CHEMBL5270628)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412076BDBM50412076(CHEMBL457817)
Affinity DataIC50: 2.80E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412083BDBM50412083(CHEMBL458033)
Affinity DataIC50: 3.50E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412081BDBM50412081(CHEMBL505436)
Affinity DataIC50: 6.80E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50396752BDBM50396752(CHEMBL2172350)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412079BDBM50412079(CHEMBL456512)
Affinity DataIC50: 7.40E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50135147BDBM50135147(N-[(5R,8S,9S,10R,13S,14S,17S)-17-((S)-1-Dimethylam...)
Affinity DataIC50: 8.00E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22984BDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Growth inhibition of multidrug resistant MCF7/Adr cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50412078BDBM50412078(EPIPACHYSAMINE D)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407450BDBM50407450(CHEMBL4544901)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
Gitam (Deemed To Be University)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50407447BDBM50407447(CHEMBL5285729)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed