Compile Data Set for Download or QSAR
Report error Found 1743 Enz. Inhib. hit(s) with Target = 'Alpha-2C adrenergic receptor'
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81811BDBM81811(MK-912 | NSC_123679 | CAS_123679 | L-657,743)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163477BDBM50163477((3R,3aS)-7-(2-Methoxy-ethoxy)-3-[4-((E)-2-methyl-3...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81806BDBM81806(WIN 53782 | 2-(4,5-dihydro-1h-imidazol-2-yl)-2,3-d...)
Affinity DataKi:  0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 81811BDBM81811(MK-912 | NSC_123679 | CAS_123679 | L-657,743)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(North American opossum)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81804BDBM81804(CAS_76727-72-5 | 4-chloro-2-(2-imidazolin-2-ylamin...)
Affinity DataKi:  0.0800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574215BDBM50574215(CHEMBL4878875 | US20240000767, Example 102)
Affinity DataIC50: 0.0850nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
US Patent

TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574215BDBM50574215(CHEMBL4878875 | US20240000767, Example 102)
Affinity DataIC50: 0.0850nMAssay Description:Inhibition of human alpha 2C adrenergic receptor expressed in CHO-K1 cells coexpressing Gaq and aequorin assessed as suppression of noradrenaline-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163479BDBM50163479(Dimethyl-(2-{(3R,3aS)-3-[4-((E)-2-methyl-3-phenyl-...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50024301BDBM50024301(CHEMBL2112985)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131346BDBM50131346((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163468BDBM50163468((3R,3aS)-3-[4-((E)-2-Methyl-3-phenyl-allyl)-pipera...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50417006BDBM50417006(CHEMBL1256414)
Affinity DataKi:  0.129nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020192BDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81815BDBM81815(CAS_196343 | NSC_196343 | L-654,284)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 85709BDBM85709(S18616)
Affinity DataKi:  0.159nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50417010BDBM50417010(CHEMBL1255723)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163489BDBM50163489(Acetic acid (3R,3aS)-3-[4-((E)-2-methyl-3-phenyl-a...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131347BDBM50131347((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-en...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163475BDBM50163475((3R,3aS)-7-[2-(2-Ethoxy-ethoxy)-ethoxy]-3-[4-((E)-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146506BDBM50146506((3R,3aS)-3-{4-[3-(3-Fluoro-phenyl)-2-methyl-allyl]...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131353BDBM50131353(7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl-allyl)-p...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131346BDBM50131346((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131347BDBM50131347((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-3-phenyl-but-2-en...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146502BDBM50146502((3R,3aS)-7,8-Dimethoxy-3-[4-(3-thiophen-2-yl-but-2...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146501BDBM50146501((3R,3aS)-3-{4-[3-(2,5-Difluoro-phenyl)-2-methyl-al...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146498BDBM50146498((3R,3aS)-7,8-Dimethoxy-3-[4-(2-methyl-3-thiophen-2...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163494BDBM50163494((3R,3aS)-7-Methoxy-3-[4-((E)-2-methyl-3-phenyl-all...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146510BDBM50146510((3R,3aS)-7,8-Dimethoxy-3-[4-(2-methyl-3-thiophen-3...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131346BDBM50131346((3R,3aS)-7,8-Dimethoxy-3-[4-((E)-2-methyl-3-phenyl...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C-adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163491BDBM50163491(Methoxy-acetic acid (3R,3aS)-3-[4-((E)-2-methyl-3-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81803BDBM81803(NSC_125992 | CAS_125992 | RX 811033)
Affinity DataKi:  0.240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574218BDBM50574218(CHEMBL4875484 | US20240000767, Example 135)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human alpha 2C adrenergic receptor expressed in CHO-K1 cells coexpressing Gaq and aequorin assessed as suppression of noradrenaline-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50020192BDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574218BDBM50574218(CHEMBL4875484 | US20240000767, Example 135)
Affinity DataIC50: 0.260nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
US Patent

TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81444BDBM81444(NSC_185453 | CAS_185453 | WB 4101 | WB-4101)
Affinity DataKi:  0.270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50020192BDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50417019BDBM50417019(CHEMBL1256378)
Affinity DataKi:  0.295nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 30993BDBM30993(Ajmalicine | MLS000111555 | SMR000107477 | Raubasi...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50163483BDBM50163483(Cyclopropanecarboxylic acid (3R,3aS)-3-[4-((E)-2-m...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity for alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146513BDBM50146513((3R,3aS)-7,8-Dimethoxy-3-[4-(3-thiophen-3-yl-but-2...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146512BDBM50146512((3R,3aS)-3-{4-[3-(4-Fluoro-phenyl)-but-2-enyl]-pip...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity to human alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Janssen-Cilag

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50574219BDBM50574219(CHEMBL4852159 | US20240000767, Example 140)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human alpha 2C adrenergic receptor expressed in CHO-K1 cells coexpressing Gaq and aequorin assessed as suppression of noradrenaline-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
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