Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with Target = 'Beta-lactamase SHV-1'
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178163BDBM178163(US9120808, Example 42 | US9120808, Example 41)
Affinity DataIC50: 0.400nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178167BDBM178167(US9120808, Example 46 | US9120808, Example 47)
Affinity DataIC50: 0.5nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178215BDBM178215(US9120808, Example 58)
Affinity DataIC50: 0.600nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178163BDBM178163(US9120808, Example 42 | US9120808, Example 41)
Affinity DataIC50: 0.800nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178170BDBM178170(US9120808, Example 49)
Affinity DataIC50: 2.60nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178171BDBM178171(US9120808, Example 50)
Affinity DataIC50: 3.20nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178167BDBM178167(US9120808, Example 46 | US9120808, Example 47)
Affinity DataIC50: 3.40nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178169BDBM178169(US9120808, Example 48)
Affinity DataIC50: 4.20nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178165BDBM178165(US9120808, Mixture of Example 43 and Example 44)
Affinity DataIC50: 4.30nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149467BDBM50149467((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178198BDBM178198(US9120808, Example 18)
Affinity DataIC50: 13.9nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212641BDBM50212641(Brobactam)
Affinity DataIC50: 17.8nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021959BDBM50021959(antibiotic MM 14151 | CHEMBL777 | MM 14151 | clavu...)
Affinity DataIC50: 20.1nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178214BDBM178214(US9120808, Example 57)
Affinity DataIC50: 22.6nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212645BDBM50212645(CHEMBL305908)
Affinity DataIC50: 26.4nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021959BDBM50021959(antibiotic MM 14151 | CHEMBL777 | MM 14151 | clavu...)
Affinity DataIC50: 28nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053173BDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataKi:  220nM IC50: 30nMpH: 7.4Assay Description:Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4). IC50, defined as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2015
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50021959BDBM50021959(antibiotic MM 14151 | CHEMBL777 | MM 14151 | clavu...)
Affinity DataIC50: 30.3nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178201BDBM178201(US9120808, Example 26)
Affinity DataIC50: 36.3nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 60600BDBM60600(US9120808, Example 13)
Affinity DataIC50: 47.7nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178203BDBM178203(US9120808, Example 34)
Affinity DataIC50: 50.3nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212644BDBM50212644(CHEMBL73450)
Affinity DataIC50: 51nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178200BDBM178200(US9120808, Example 24)
Affinity DataIC50: 62.2nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212638BDBM50212638(CHEMBL302512)
Affinity DataIC50: 72nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178196BDBM178196(US9120808, Example 16)
Affinity DataIC50: 80.5nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021959BDBM50021959(antibiotic MM 14151 | CHEMBL777 | MM 14151 | clavu...)
Affinity DataKi:  2.00E+3nM IC50: 100nMpH: 7.4Assay Description:Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4). IC50, defined as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2015
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212634BDBM50212634(CHEMBL309009)
Affinity DataIC50: 104nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053173BDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053173BDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50: 133nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212643BDBM50212643(CHEMBL308516)
Affinity DataIC50: 141nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178204BDBM178204(US9120808, Example 37)
Affinity DataIC50: 141nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212642BDBM50212642(CHEMBL70269)
Affinity DataIC50: 146nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218934BDBM50218934(sodium (8S,9R)-10(E)-ethylidene-4(S)-(2'-fluoroeth...)
Affinity DataIC50: 148nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218935BDBM50218935(sodium (8S,9R)-10(E)-ethylidene-4(S)-methoxy-11-ox...)
Affinity DataIC50: 151nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218936BDBM50218936(sodium (8S,9R)-10(E)-ethylidene-4(S)-(2'-cyanoetho...)
Affinity DataIC50: 152nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021959BDBM50021959(antibiotic MM 14151 | CHEMBL777 | MM 14151 | clavu...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021959BDBM50021959(antibiotic MM 14151 | CHEMBL777 | MM 14151 | clavu...)
Affinity DataIC50: 170nMAssay Description:Inhibition of Klebsiella pneumoniae Beta-Lactamase SHV-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218939BDBM50218939(sodium (5S,8aS,8bR)-5-butoxy-1-eth-(E)-ylidene-2-o...)
Affinity DataIC50: 206nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178188BDBM178188(US9120808, Example 7)
Affinity DataIC50: 217nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218932BDBM50218932(sodium (8R,9R)-10(S)-[1(R)-hydroxyethyl]-4(R)-buto...)
Affinity DataIC50: 219nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178210BDBM178210(US9120808, Example 53)
Affinity DataIC50: 219nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053173BDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50: 222nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50053173BDBM50053173((2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-[1,2,3]triazol-...)
Affinity DataIC50: 222nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218933BDBM50218933(sodium (8R,9R)-10(E)-ethylidene-4(R)-ethoxy-11-oxo...)
Affinity DataIC50: 284nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178211BDBM178211(US9120808, Example 54)
Affinity DataIC50: 295nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 152696BDBM152696(PSR-3-283A)
Affinity DataKi:  560nM IC50: 320nMpH: 7.4Assay Description:Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4). IC50, defined as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2015
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Escherichia coli)
Nabriva Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 178202BDBM178202(US9120808, Example 32)
Affinity DataIC50: 339nMpH: 7.0 T: 2°CAssay Description:The inhibitory concentrations (IC50, [uM]) of the beta -lactamase inhibitors against purified TEM-1, SHV-1 and AmpC beta -lactamases are assessed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details
US Patent

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218938BDBM50218938(sodium (8S,9R)-10(E)-ethylidene-4(S)-isopropoxy-11...)
Affinity DataIC50: 340nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50212637BDBM50212637(CHEMBL72046)
Affinity DataIC50: 370nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50218937BDBM50218937(sodium (8S,9R)-10(E)-ethylidene-4(S)-ethoxy-11-oxo...)
Affinity DataIC50: 385nMAssay Description:Inhibition of Escherichia coli SHV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
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