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Found 22 Enz. Inhib. hit(s) with Target = 'Betaine--homocysteine S-methyltransferase 1'
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human recombinant BHMT expressed in Escherichia coli using variable levels of betaine substrate by Dixon plotMore data for this Ligand-Target Pair
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268080((S)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylpe...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268079((RS)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylp...)
Affinity DataIC50:  84nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataIC50:  87nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189914((R,S)-2-amino-4-(2-carboxymethylsulfanyl-ethylsulf...)
Affinity DataIC50:  96nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataIC50:  138nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268078((RS,RS)-5-(3-Amino-3-carboxypropylthio)-3-methylpe...)
Affinity DataIC50:  139nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189912((R,S)-6-(3-amino-3-carboxy-propylsulfanyl)-hexanoi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268032((RS)-5-(3-Amino-3-carboxypropylselanyl)pentanoic A...)
Affinity DataIC50:  649nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268081((R)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylpe...)
Affinity DataIC50:  701nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50436836(CHEMBL2403304)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268055((RS)-2-Amino-4-{2-[(carboxymethyl)(methyl)amino]et...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268031((RS)-2-Amino-4-[(2-carboxyethylthio)methylthio]but...)
Affinity DataIC50:  3.26E+3nMAssay Description:Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189915((R,S)-5-(3-amino-3-carboxy-propylsulfinyl)-pentano...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50436835(CHEMBL2403303)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189916((R,S)-2-amino-4-(4-phosphono-butylsulfanyl)-butyri...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189913((R,S)-4-(3-amino-3-carboxy-propylsulfanyl)-benzoic...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human BHMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50395382(CHEMBL2164724)
Affinity DataIC50:  7.66E+4nMAssay Description:Inhibition of recombinant human BHMT expressed in Escherichia coli BL31(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50436834(CHEMBL2403302)
Affinity DataIC50:  2.19E+5nMAssay Description:Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50189917((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...)
Affinity DataKd:  280nMAssay Description:Binding affinity to human recombinant BHMT expressed in Escherichia coli by intrinsic tryptophan fluorescence studiesMore data for this Ligand-Target Pair
TargetBetaine--homocysteine S-methyltransferase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50268080((S)-5-(3-Amino-3-carboxypropylthio)-3,3-dimethylpe...)
Affinity DataKd:  83nMAssay Description:Binding affinity to human recombinant BHMT expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed