Compile Data Set for Download or QSAR
Report error Found 998 Enz. Inhib. hit(s) with Target = 'Botulinum neurotoxin type A'
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506811BDBM506811(US11046652, Example 1-5)
Affinity DataKi:  3.20nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506825BDBM506825(US11046652, Example 2-4)
Affinity DataKi:  4.5nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506834BDBM506834(US11046652, Example 3-7)
Affinity DataKi:  5.10nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506835BDBM506835(US11046652, Example 3-8)
Affinity DataKi:  5.40nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506829BDBM506829(US11046652, Example 3-2)
Affinity DataKi:  5.40nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506807BDBM506807(US11046652, Example 2-1 | US11046652, Example 1-1)
Affinity DataKi:  5.70nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506807BDBM506807(US11046652, Example 2-1 | US11046652, Example 1-1)
Affinity DataKi:  6.10nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506813BDBM506813(US11046652, Example 1-7)
Affinity DataKi:  6.20nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506808BDBM506808(US11046652, Example 1-3 | US11046652, Example 1-2)
Affinity DataKi:  6.40nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506832BDBM506832(US11046652, Example 3-5)
Affinity DataKi:  6.40nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506841BDBM506841(US11046652, Example 5-1)
Affinity DataKi:  7.10nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506815BDBM506815(US11046652, Example 1-9)
Affinity DataKi:  8.20nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506833BDBM506833(US11046652, Example 3-6)
Affinity DataKi:  9.5nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506828BDBM506828(US11046652, Example 3-1)
Affinity DataKi:  10.2nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129806BDBM50129806(CHEMBL3627987)
Affinity DataKi:  12nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue preincubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506810BDBM506810(US11046652, Example 1-4)
Affinity DataKi:  13.8nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506814BDBM506814(US11046652, Example 1-8)
Affinity DataKi:  14.7nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506821BDBM506821(US11046652, Example 1-15)
Affinity DataKi:  17.8nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506812BDBM506812(US11046652, Example 1-6)
Affinity DataKi:  18nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506819BDBM506819(US11046652, Example 1-13)
Affinity DataKi:  19nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506820BDBM506820(US11046652, Example 1-14)
Affinity DataKi:  20.4nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506808BDBM506808(US11046652, Example 1-3 | US11046652, Example 1-2)
Affinity DataKi:  21.3nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506823BDBM506823(US11046652, Example 2-2)
Affinity DataKi:  24.5nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129806BDBM50129806(CHEMBL3627987)
Affinity DataKi:  26nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP absent during reaction by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50067697BDBM50067697(7-chloro-N-(3-(3-(7-chloroquinolin-4-ylamino)propy...)
Affinity DataIC50: 26nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506824BDBM506824(US11046652, Example 2-3)
Affinity DataKi:  26nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429171BDBM50429171(CHEMBL2336714)
Affinity DataKi:  27nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429170BDBM50429170(CHEMBL2336715)
Affinity DataKi:  27nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506818BDBM506818(US11046652, Example 1-12)
Affinity DataKi:  28nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429171BDBM50429171(CHEMBL2336714)
Affinity DataIC50: 30nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506837BDBM506837(US11046652, Example 3-11 | US11046652, Example 3-1...)
Affinity DataKi:  30.6nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506836BDBM506836(US11046652, Example 3-9)
Affinity DataKi:  31.7nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506840BDBM506840(US11046652, Example 4-2)
Affinity DataKi:  33.3nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129806BDBM50129806(CHEMBL3627987)
Affinity DataKi:  39nMAssay Description:Inhibition of Clostridium botulinum truncated-BoNT/A light chain 424 residue preincubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506816BDBM506816(US11046652, Example 1-10)
Affinity DataKi:  39.8nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429170BDBM50429170(CHEMBL2336715)
Affinity DataIC50: 40nMAssay Description:Inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAPtide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50534918BDBM50534918(CHEMBL4474592)
Affinity DataKi:  41nMAssay Description:Inhibition of protease activity of Clostridium botulinum BoNT/A using N(K)-acetyl)-SNKTRIDEANQRATKML-carboxamide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506817BDBM506817(US11046652, Example 1-11)
Affinity DataKi:  44nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129806BDBM50129806(CHEMBL3627987)
Affinity DataKi:  46nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP absent during reaction by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506837BDBM506837(US11046652, Example 3-11 | US11046652, Example 3-1...)
Affinity DataKi:  53nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50447108BDBM50447108(CHEMBL3112881)
Affinity DataKi:  77nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50447108BDBM50447108(CHEMBL3112881)
Affinity DataKi:  77nMAssay Description:Inhibition of Clostridium botulinum BoNT/A LC assessed as cleavage of SNAP-25 (141 to 206) after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50013677BDBM50013677(CHEMBL3264512)
Affinity DataKi:  103nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A [1-429](Clostridium botulinum (strain Hall / ATCC 3502 / N...)
Hawaii Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 506827BDBM506827(US11046652, Example 2-6)
Affinity DataKi:  118nMAssay Description:In a 96 well, clear bottom black plate, the following was added to each well: 5 nM BoNT/A LC1-429, 28 μM substrate in 30 mM HEPES pH 7.3, 0.05 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429172BDBM50429172(CHEMBL2336713)
Affinity DataKi:  130nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50447108BDBM50447108(CHEMBL3112881)
Affinity DataIC50: 150nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129806BDBM50129806(CHEMBL3627987)
Affinity DataKi:  157nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 30 mins and TCEP present during reaction by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429169BDBM50429169(CHEMBL2336719)
Affinity DataKi:  160nMAssay Description:Competitive inhibition of Clostridium botulinum BoNT/A Hall A hyper protease light chain (1-425aa) using SNAP-66mer (141-206aa) as substrate by FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129806BDBM50129806(CHEMBL3627987)
Affinity DataKi:  162nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain 448 residue coincubated with TCEP for 60 mins and TCEP present during reaction by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Brookhaven National Laboratory

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50013673BDBM50013673(CHEMBL3264509)
Affinity DataKi:  171nMAssay Description:Inhibition of Clostridium botulinum recombinant BoNT/A light chain using N-terminal acetylated, C-terminal aminated SNAP-25 (187-203) as substrate by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
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