Compile Data Set for Download or QSAR
Report error Found 51 Enz. Inhib. hit(s) with Target = 'C-1-tetrahydrofolate synthase, cytoplasmic'
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  87nMAssay Description:Binding affinity to human MTHFD1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535669BDBM50535669(CHEMBL1233930)
Affinity DataIC50: 96nMAssay Description:Inhibition of His-tagged human MTHFD1 ( 1 to 306 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before folitixorin and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509364BDBM50509364(CHEMBL4463968)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509346BDBM50509346(CHEMBL4470947)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509362BDBM50509362(CHEMBL4483030)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509354BDBM50509354(CHEMBL4542665)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509356BDBM50509356(CHEMBL4584730)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509350BDBM50509350(CHEMBL4441993)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509358BDBM50509358(CHEMBL4534641)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509361BDBM50509361(CHEMBL4441792)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509353BDBM50509353(CHEMBL4546647)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509360BDBM50509360(CHEMBL4538356)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509351BDBM50509351(CHEMBL4460077)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580116BDBM50580116(CHEMBL5093943)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580117BDBM50580117(CHEMBL5076176)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580118BDBM50580118(CHEMBL5094059)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580119BDBM50580119(CHEMBL5082640)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580120BDBM50580120(CHEMBL5077920)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580121BDBM50580121(CHEMBL5085594)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580122BDBM50580122(CHEMBL5074925)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50365463BDBM50365463(CHEMBL1232461)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MTHFD1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580112BDBM50580112(CHEMBL5077748)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580113BDBM50580113(CHEMBL5090659)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580114BDBM50580114(CHEMBL5075801)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50580115BDBM50580115(CHEMBL5084848)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged human MTHFD1 (1 to 306 residues) expressed in insect cells using tetrahydrofolate as substrate preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509359BDBM50509359(CHEMBL4474051)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509348BDBM50509348(CHEMBL4458187)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509344BDBM50509344(CHEMBL4460238)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509343BDBM50509343(CHEMBL4472668)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509342BDBM50509342(CHEMBL4438430)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509363BDBM50509363(CHEMBL4467997)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535655BDBM50535655(CHEMBL4440948)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535654BDBM50535654(CHEMBL4459818)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535670BDBM50535670(CHEMBL4448164)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535652BDBM50535652(CHEMBL4547499)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509345BDBM50509345(CHEMBL4592118)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535653BDBM50535653(CHEMBL4530832)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535651BDBM50535651(CHEMBL4543120)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535674BDBM50535674(CHEMBL4538051)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509355BDBM50509355(CHEMBL4551634)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535659BDBM50535659(CHEMBL4474283)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535658BDBM50535658(CHEMBL4465667)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509352BDBM50509352(CHEMBL4451401)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535657BDBM50535657(CHEMBL4469262)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509357BDBM50509357(CHEMBL4473116)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509349BDBM50509349(CHEMBL4436668)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50509347BDBM50509347(CHEMBL4526400)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant MTHFD1 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.03E+4nMAssay Description:Binding affinity to human MTHFD1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50028981BDBM50028981(2-{4-[2-(2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahy...)
Affinity DataKi:  4.10E+4nMAssay Description:Compound was tested for in vitro inhibition of 5,10-Methylene Tetrahydrofolate Cyclohydrolase, competitive against (+)-L-5,10-methenyltetrahydrofolat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243415BDBM50243415(CHEMBL4063104)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MTHFD1 (unknown origin) using NADP/5,10-methylene THF as substrate after 30 mins by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
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