Compile Data Set for Download or QSAR
Report error Found 1276 Enz. Inhib. hit(s) with Target = 'Cruzipain'
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603782(CHEMBL4596414)
Affinity DataIC50: 0.0810nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50602542(CHEMBL4594870)
Affinity DataIC50: 0.0860nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50602545(CHEMBL4596647)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50331776((S)-4,4-dichloro-N-((S)-1-cyano-2-phenylethyl)-2-(...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Trypanosoma cruzi CruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603794(CHEMBL5184737)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603779(CHEMBL3558756)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603788(CHEMBL5171874)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603795(CHEMBL5175270)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50602544(CHEMBL4594757)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataKi:  0.200nMAssay Description:Time dependent inhibition of Trypanosoma cruzi cruzain using Cbz-Phe-Arg-AMC as substrate assessed as inhibition constant for EI complex measured for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50331769((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Trypanosoma cruzi CruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50331767(1-(4'-((S)-1-((S)-1-((S)-1-cyano-2-(4-cyano-2-fluo...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Trypanosoma cruzi CruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-AMC as substrate by spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50214542((S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanes...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Trypanosoma cruzi CruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50505555(CHEMBL4447348)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603793(CHEMBL5199542)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603792(CHEMBL5176188)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50303422(cid_44142124 | CHEMBL578162 | 6-(3-chlorophenylami...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603781(CHEMBL4596941)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50331768((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Trypanosoma cruzi CruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50303421(6-(3-Chlorophenylamino)-9-ethyl-9H-purine-2-carbon...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50331768((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 0.400nMAssay Description:Reversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603789(CHEMBL5183942)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50201259(CHEMBL3907022)
Affinity DataKi:  0.440nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi:  0.440nMAssay Description:All enzyme assays were performed at 25° C. Initial rates of the peptidolytic reaction catalyzed by cruzain were measured by monitoring the fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
US Patent

TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50286450([(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-pheny...)
Affinity DataKi:  0.440nMAssay Description:Time dependent inhibition of Trypanosoma cruzi cruzain using Cbz-Phe-Arg-AMC as substrate assessed as inhibition constant for EI complex measured for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50505557(CHEMBL4527930)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603783(CHEMBL4595806)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50505568(CHEMBL4482954)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50581372(CHEMBL5079418)
Affinity DataKi:  0.5nMAssay Description:Time dependent inhibition of Trypanosoma cruzi cruzain using Cbz-Phe-Arg-AMC as substrate assessed as inhibition constant for EI complex measured for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50502827(CHEMBL4565840)
Affinity DataKi:  0.631nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603790(CHEMBL5191563)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603796(CHEMBL5204190)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603787(CHEMBL4597308)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50505562(CHEMBL4445744)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603780(CHEMBL4596992)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50505554(CHEMBL4564747)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603791(CHEMBL5179302)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50505322(CHEMBL4557939)
Affinity DataIC50: 0.800nMAssay Description:Reversible inhibition of Trypanosoma cruzi cruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50505563(CHEMBL4527329)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50603786(CHEMBL4595664)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50108858({1-[2-Oxo-1-phenethyl-3-(3-phenyl-propylsulfanyl)-...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory activity against cruzain, the major cysteine protease found in Trypanosoma cruziMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50108858({1-[2-Oxo-1-phenethyl-3-(3-phenyl-propylsulfanyl)-...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory activity against cruzain, the major cysteine protease found in Trypanosoma cruziMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50108847({1-[1-Benzyl-2-oxo-3-(3-phenyl-propylsulfanyl)-pro...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against cruzain, the major cysteine protease found in Trypanosoma cruziMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Trypanosoma cruzi CruzipainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50303419(4-(2,2-difluoroethylamino)-6-(3,5-difluorophenylam...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50108847({1-[1-Benzyl-2-oxo-3-(3-phenyl-propylsulfanyl)-pro...)
Affinity DataKi:  1nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50303434(4-(cyclopentylamino)-6-(3-nitrophenylamino)-1,3,5-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
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