Compile Data Set for Download or QSAR
Report error Found 1971 Enz. Inhib. hit(s) with Target = 'Cyclic GMP-AMP synthase'
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648831BDBM50648831(CHEMBL5612485)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648831BDBM50648831(CHEMBL5612485)
Affinity DataIC50: 1nMAssay Description:Inhibition of cGAS in dsDNA stimulated human Whole blood cell by measuring IFNalpha-2a production incubated for 60 mins followed by addition of doubl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700823BDBM700823(US20240342186, Example 2.04)
Affinity DataIC50: 1nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648829BDBM50648829(CHEMBL5614320)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 805489BDBM805489(WO2023183275, Compound 22A*)
Affinity DataIC50: 1.70nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 805426BDBM805426((S)-2-((2-(4-chloro-5-fluoro-11-methyl-1,2,8,9-tet...)
Affinity DataIC50: 1.70nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685892BDBM685892(US12043625, Example 3.01)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685859BDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685859BDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685851BDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685893BDBM685893(US12043625, Example 3.02)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688400BDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685857BDBM685857(US12043625, Example 1.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700795BDBM700795(US20240342186, Example 1.11)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700793BDBM700793(US20240342186, Example 1.09)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700824BDBM700824(US20240342186, Example 2.05)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685878BDBM685878(US12043625, Example 2.07)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685859BDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700804BDBM700804(US20240342186, Example 1.20)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688400BDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685874BDBM685874(US12043625, Example 2.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50649732BDBM50649732(CHEMBL5620249)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length his-tagged human recombinant cGAS extracted from Escherichia coli BL21 (DE3) incubated for 3 hrs by rapidfire 365 mass spec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685851BDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685851BDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685882BDBM685882(US12043625, Example 2.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688400BDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685849BDBM685849(US12043625, Example 1.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648831BDBM50648831(CHEMBL5612485)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal 6His-SUMO tagged human cGAS (1 to 522 residues) extracted from Escherichia coli BL21(DE3)pLysS cells using GTP/ATP as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651824BDBM50651824(CHEMBL5641551)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of cyclic GMP-AMP synthase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648827BDBM50648827(CHEMBL5612416)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 805487BDBM805487(WO2023183275, Compound 8A*)
Affinity DataIC50: 2.5nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 805405BDBM805405((S)-2-amino-1-(8-chloro-7-fluoro-9-methoxy-1-methy...)
Affinity DataIC50: 2.5nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 805367BDBM805367((S)-1-(4,5-dichloro-11-methyl-1,2,8,9-tetrahydrofu...)
Affinity DataIC50: 2.60nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648829BDBM50648829(CHEMBL5614320)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal 6His-SUMO tagged human cGAS (1 to 522 residues) extracted from Escherichia coli BL21(DE3)pLysS cells using GTP/ATP as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688363BDBM688363(US20240189315, Example 11)
Affinity DataIC50: 2.80nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648826BDBM50648826(CHEMBL5614182)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of N-terminal 6His-SUMO tagged human cGAS (1 to 522 residues) extracted from Escherichia coli BL21(DE3)pLysS cells using GTP/ATP as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 805390BDBM805390(1-((3aR,5S,11aS)-8-chloro-9-fluoro-7-methoxy-5-met...)
Affinity DataIC50: 2.80nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/17/2026
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50648826BDBM50648826(CHEMBL5614182)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700822BDBM700822(US20240342186, Example 2.03)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700817BDBM700817(US20240342186, Example 1.33)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700818BDBM700818(US20240342186, Example 1.34)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700815BDBM700815(US20240342186, Example 1.31)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685883BDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700829BDBM700829(US20240342186, Example 2.10)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700827BDBM700827(US20240342186, Example 2.08)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700826BDBM700826(US20240342186, Example 2.07)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688404BDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 685872BDBM685872(US12043625, Example 2.01)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688392BDBM688392(US20240189315, Example 38)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 700800BDBM700800(US20240342186, Example 1.16)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

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