Compile Data Set for Download or QSAR
Report error Found 587 Enz. Inhib. hit(s) with Target = 'Cyclin-K/Cyclin-dependent kinase 12'
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724589BDBM724589(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 3.09nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724595BDBM724595(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 4.14nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 50139171BDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50: 5nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724593BDBM724593(2-(morpholin-4-yl)-N-({5-[6-(trifluoromethoxy)pyri...)
Affinity DataIC50: 5.96nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724587BDBM724587(2-(morpholin-4-yl)-N-({5-[4-(trifluoromethoxy)phen...)
Affinity DataIC50: 7.59nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724585BDBM724585(2-(morpholin-4-yl)-N-({5-[4-(trifluoromethoxy)phen...)
Affinity DataIC50: 8.34nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724586BDBM724586(2-(morpholin-4-yl)-8-(trifluoromethyl)-N-({5-[4-(t...)
Affinity DataIC50: 9.21nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724596BDBM724596(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 11.9nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 729623BDBM729623(US20250101023, Example 49)
Affinity DataIC50: 12nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724590BDBM724590(N-{[5-(4-methoxyphenyl)-1H-imidazol-2-yl]methyl}-2...)
Affinity DataIC50: 12.3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724599BDBM724599(2-(morpholin-4-yl)-8-(trifluoromethyl)-N-({5-[6-(t...)
Affinity DataIC50: 15.1nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 729620BDBM729620(US20250101023, Example 46)
Affinity DataIC50: 16nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788188BDBM788188(US12473303, Compound H-APPAMP-045)
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 729624BDBM729624(US20250101023, Example 50)
Affinity DataIC50: 19nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788150BDBM788150(US12473303, Compound H-APPAMP-007)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788186BDBM788186(US12473303, Compound H-APPAMP-043)
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 738790BDBM738790(US20250145632, Example Z2)
Affinity DataKi:  22.7nMAssay Description:This experiment was used for determining the inhibition of the activities of CDK2, CDK7, CDK9 and CDK12 kinases by the compound. The kinase reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788174BDBM788174(US12473303, Compound H-APPAMP-031)
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788155BDBM788155(US12473303, Compound H-APPAMP-012)
Affinity DataIC50: 26nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 738791BDBM738791(US20250145632, Example Z5)
Affinity DataKi:  26.1nMAssay Description:This experiment was used for determining the inhibition of the activities of CDK2, CDK7, CDK9 and CDK12 kinases by the compound. The kinase reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724584BDBM724584(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[4-(t...)
Affinity DataIC50: 26.3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788149BDBM788149(US12473303, Compound H-APPAMP-006)
Affinity DataIC50: 26.9nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788170BDBM788170(US12473303, Compound H-APPAMP-027)
Affinity DataIC50: 28nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 729626BDBM729626(US20250101023, Example 53)
Affinity DataIC50: 30nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788169BDBM788169(US12473303, Compound H-APPAMP-026)
Affinity DataIC50: 31nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724588BDBM724588(2-(morpholin-4-yl)-7-(trifluoromethyl)-N-({5-[4-(t...)
Affinity DataIC50: 32.3nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788154BDBM788154(US12473303, Compound H-APPAMP-011)
Affinity DataIC50: 33nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724581BDBM724581(8-bromo-2-(morpholin-4-yl)-N-({5-[4-(trifluorometh...)
Affinity DataIC50: 34.8nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788168BDBM788168(US12473303, Compound H-APPAMP-025)
Affinity DataIC50: 36nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788171BDBM788171(US12473303, Compound H-APPAMP-028)
Affinity DataIC50: 37nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788152BDBM788152(US12473303, Compound H-APPAMP-009)
Affinity DataIC50: 38nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788144BDBM788144(US12473303, Compound H-APPAMP-001)
Affinity DataIC50: 38nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788153BDBM788153(US12473303, Compound H-APPAMP-010)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788187BDBM788187(US12473303, Compound H-APPAMP-044)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788151BDBM788151(US12473303, Compound H-APPAMP-008)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 724594BDBM724594(N-{[5-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-y...)
Affinity DataIC50: 41.6nMAssay Description:For the assay 50 nanoL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788178BDBM788178(US12473303, Compound H-APPAMP-035)
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788175BDBM788175(US12473303, Compound H-APPAMP-032)
Affinity DataIC50: 45nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788184BDBM788184(US12473303, Compound H-APPAMP-041)
Affinity DataIC50: 46nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788182BDBM788182(US12473303, Compound H-APPAMP-039)
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788183BDBM788183(US12473303, Compound H-APPAMP-040)
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 50528813BDBM50528813(CHEMBL4163879 | US20250101023, Example THZ531)
Affinity DataIC50: 50nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788146BDBM788146(US12473303, Compound H-APPAMP-003)
Affinity DataIC50: 50.2nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 729597BDBM729597(US20250101023, Example 20)
Affinity DataIC50: 51nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 788147BDBM788147(US12473303, Compound H-APPAMP-004)
Affinity DataIC50: 51.7nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/8/2026
Entry Details US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 50367676BDBM50367676(CHEMBL4160662)
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 729610BDBM729610(US20250101023, Example 35)
Affinity DataIC50: 53nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 729625BDBM729625(US20250101023, Example 51)
Affinity DataIC50: 56nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 738792BDBM738792(US20250145632, Example Z7)
Affinity DataKi:  61.4nMAssay Description:This experiment was used for determining the inhibition of the activities of CDK2, CDK7, CDK9 and CDK12 kinases by the compound. The kinase reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Deutsches Krebsforschungszentrum

US Patent
LigandChemical structure of BindingDB Monomer ID 738793BDBM738793(US20250145632, Example Z65)
Affinity DataKi:  61.6nMAssay Description:This experiment was used for determining the inhibition of the activities of CDK2, CDK7, CDK9 and CDK12 kinases by the compound. The kinase reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

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