Compile Data Set for Download or QSAR
Report error Found 167 Enz. Inhib. hit(s) with Target = 'Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]'
LigandPNGBDBM297409(US10117858, Example 16 | US20240058315, Example 17)
Affinity DataEC50:  8nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM297409(US10117858, Example 16 | US20240058315, Example 17)
Affinity DataEC50:  10nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM297396(US10117858, Example 2 | 3-Amino-6-bromo-5-trifluor...)
Affinity DataEC50:  15nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM526510(US11186566, Compound 49)
Affinity DataEC50:  20nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526467(US11186566, Compound 4)
Affinity DataEC50:  20nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526476(US11186566, Compound 15)
Affinity DataEC50:  20nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526477(US11186566, Compound 16)
Affinity DataEC50:  20nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526464(US11186566, Compound 17 | US11186566, Compound 1)
Affinity DataEC50:  30nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526511(US11186566, Compound 50)
Affinity DataEC50:  30nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526484(US11186566, Compound 23)
Affinity DataEC50:  30nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526489(US11186566, Compound 28)
Affinity DataEC50:  30nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526492(US11186566, Compound 31)
Affinity DataEC50:  30nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM297403(US10117858, Example 12 | 3-Amino-6-methoxy-5-trifl...)
Affinity DataEC50:  35nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM297401(US10117858, Example 11 | 3-Amino-6-(4-fluoro-pheny...)
Affinity DataEC50:  37nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM526514(US11186566, Compound 53)
Affinity DataEC50:  40nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526471(US11186566, Compound 10)
Affinity DataEC50:  40nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526493(US11186566, Compound 32)
Affinity DataEC50:  40nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM297406(US10117858, Example 7 | 3-Amino-6-(4-fluoro-phenyl...)
Affinity DataEC50:  40nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM526475(US11186566, Compound 14)
Affinity DataEC50:  40nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526512(US11186566, Compound 51)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526516(US11186566, Compound 55)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526468(US11186566, Compound 5)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526519(US11186566, Compound 58)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526523(US11186566, Compound 64 | US11186566, Compound 63)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526504(US11186566, Compound 43)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526503(US11186566, Compound 42)
Affinity DataEC50:  50nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  50nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM297407(US10117858, Example 15 | 5-Amino-6′-methyl-3...)
Affinity DataEC50:  51nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM297398(US10117858, Example 3 | 3-Amino-6-bromo-5-trifluor...)
Affinity DataEC50:  55nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM297408(US10117858, Example 8 | 3-Amino-6-(4-fluoro-phenyl...)
Affinity DataEC50:  60nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM526526(US11186566, Compound A)
Affinity DataEC50:  60nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526502(US11186566, Compound 41)
Affinity DataEC50:  70nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526485(US11186566, Compound 24)
Affinity DataEC50:  70nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526498(US11186566, Compound 37)
Affinity DataEC50:  70nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526500(US11186566, Compound 39)
Affinity DataEC50:  70nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM297400(US10117858, Example 6 | US10117858, Example 4 | US...)
Affinity DataEC50:  76nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM526494(US11186566, Compound 33)
Affinity DataEC50:  80nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526501(US11186566, Compound 40)
Affinity DataEC50:  80nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526518(US11186566, Compound 57)
Affinity DataEC50:  80nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526491(US11186566, Compound 36 | US11186566, Compound 30)
Affinity DataEC50:  90nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM297397(US10117858, Example 9 | US10117858, Example 10 | U...)
Affinity DataEC50:  90nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM526464(US11186566, Compound 17 | US11186566, Compound 1)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526466((S)—N-((4-Hydroxy-3-methoxyphenyl)sulfonyl)-6...)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526467(US11186566, Compound 4)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526468(US11186566, Compound 5)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526469(US11186566, Compound 8)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526471(US11186566, Compound 10)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526473(US11186566, Compound 12)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526475(US11186566, Compound 14)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

LigandPNGBDBM526476(US11186566, Compound 15)
Affinity DataEC50: <100nMAssay Description:The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

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