Compile Data Set for Download or QSAR
Report error Found 52 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase type 1'
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405988BDBM50405988(CHEMBL57343)
Affinity DataKi:  9.5nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405956BDBM50405956(CHEMBL57383)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405998BDBM50405998(CHEMBL300114)
Affinity DataKi:  16nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50029763BDBM50029763(Epiroprim | TCMDC-137295 | 5-(3,5-Diethoxy-4-pyrro...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110758BDBM50110758(5-(4-(benzyloxy)-3-ethoxybenzyl)pyrimidine-2,4-dia...)
Affinity DataKi:  45nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405974BDBM50405974(CHEMBL56129)
Affinity DataKi:  74nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405984BDBM50405984(CHEMBL434787)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138687BDBM50138687(5-(4-(benzyloxy)benzyl)pyrimidine-2,4-diamine | 5-...)
Affinity DataKi:  129nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210934BDBM210934(UCP1206)
Affinity DataIC50: 180nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405964BDBM50405964(CHEMBL298955)
Affinity DataKi:  251nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405995BDBM50405995(CHEMBL31055)
Affinity DataKi:  269nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210930BDBM210930(UCP1173)
Affinity DataIC50: 270nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210932BDBM210932(UCP1191)
Affinity DataIC50: 320nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210933BDBM210933(UCP1205)
Affinity DataIC50: 340nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210927BDBM210927(UCP1039)
Affinity DataIC50: 360nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210929BDBM210929(UCP1172)
Affinity DataIC50: 410nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291785BDBM50291785(6,6-Dimethyl-1-(3-m-tolyloxymethyl-phenyl)-1,6-dih...)
Affinity DataKi:  537nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405963BDBM50405963(CHEMBL19414)
Affinity DataKi:  631nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291800BDBM50291800(6,6-Dimethyl-1-(3-undecyloxy-phenyl)-1,6-dihydro-[...)
Affinity DataKi:  646nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291795BDBM50291795({3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-...)
Affinity DataKi:  646nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405099BDBM50405099(CHEMBL33750)
Affinity DataKi:  676nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405076BDBM50405076(CHEMBL269704)
Affinity DataKi:  708nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405037BDBM50405037(CHEMBL33558)
Affinity DataKi:  871nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291782BDBM50291782(3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  891nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405087BDBM50405087(CHEMBL7435)
Affinity DataKi:  891nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291797BDBM50291797(6,6-Dimethyl-1-{3-[2-(3-trifluoromethyl-phenoxy)-e...)
Affinity DataKi:  912nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291783BDBM50291783(1-[3-(3-Methoxy-phenoxymethyl)-phenyl]-6,6-dimethy...)
Affinity DataKi:  955nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291789BDBM50291789(1-[3-(3-Chloro-phenoxymethyl)-phenyl]-6,6-dimethyl...)
Affinity DataKi:  977nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291806BDBM50291806(1-[3-(Adamantan-1-ylmethoxy)-phenyl]-6,6-dimethyl-...)
Affinity DataKi:  977nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210931BDBM210931(UCP1175)
Affinity DataIC50: 980nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291778BDBM50291778(N-{3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazi...)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291802BDBM50291802(1-[3-(3-Ethyl-phenoxymethyl)-phenyl]-6,6-dimethyl-...)
Affinity DataKi:  1.12E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50225441BDBM50225441(CHEMBL59212)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291771BDBM50291771({3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-...)
Affinity DataKi:  1.23E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405069BDBM50405069(CHEMBL287235)
Affinity DataKi:  1.32E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50090054BDBM50090054(1-(3-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-...)
Affinity DataKi:  1.35E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291801BDBM50291801(6,6-Dimethyl-1-(3-tetradecyloxy-phenyl)-1,6-dihydr...)
Affinity DataKi:  1.41E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405083BDBM50405083(CHEMBL267499)
Affinity DataKi:  1.41E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405067BDBM50405067(CHEMBL32063)
Affinity DataKi:  1.78E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291793BDBM50291793(6,6-Dimethyl-1-(3-trifluoromethyl-phenyl)-1,6-dihy...)
Affinity DataKi:  2.04E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405089BDBM50405089(CHEMBL268414)
Affinity DataKi:  2.63E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291779BDBM50291779(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  3.09E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405059BDBM50405059(CHEMBL7070)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291780BDBM50291780(1-(3-Benzyloxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1...)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 210928BDBM210928(UCP1164)
Affinity DataIC50: 8.80E+3nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1 from Tn4003(Staphylococcus aureus)
University of Connecticut

LigandChemical structure of BindingDB Monomer ID 18069BDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 1.51E+4nMAssay Description:IC50 values were determined following a standard method that has been described previously (Reeve et al., 2014, 2016).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291798BDBM50291798(1-(3-tert-Butyl-phenyl)-6,6-dimethyl-1,6-dihydro-[...)
Affinity DataKi:  1.91E+4nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50090067BDBM50090067(6,6-Dimethyl-1-phenyl-1,6-dihydro-[1,3,5]triazine-...)
Affinity DataKi:  3.09E+4nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291776BDBM50291776(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  2.04E+5nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
TargetDihydrofolate reductase type 1(Escherichia coli)
Pomona College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50291777BDBM50291777(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  3.31E+5nMAssay Description:Inhibition of Escherichia coli dihydrofolate reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2018
Entry Details Article
PubMed
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