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Report error Found 270 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 2'
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531540BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531540BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 1.80nMAssay Description:Non competitive inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.90nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 142744BDBM142744(US8937095, 6)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 142744BDBM142744(US8937095, 6)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50413752BDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  9.90nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  13nMAssay Description:Binding affinity to human MAP2K2 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355504BDBM50355504(CHEMBL1908393)
Affinity DataKd:  13nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 14.6nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50413752BDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK2 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50531540BDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50132260BDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataIC50: 17nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 130909BDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human MEK2 using ERK2 (K52R) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50161957BDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKd:  26nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  28nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  28nMAssay Description:Binding constant for full-length MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31096BDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  28nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 37.4nMAssay Description:Inhibition of human MEK2 using ERK2 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50248946BDBM50248946(CHEMBL1908392 | US10981896, Compound 16 | Nintedan...)
Affinity DataKd:  42nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 520650BDBM520650(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Affinity DataIC50: 47nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 520650BDBM520650(US11147816, Refametinib (RDEA119, Bay | US11701360...)
Affinity DataIC50: 47nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105742BDBM50105742(trans -1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 15458BDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50072147BDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50072147BDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50072147BDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 58nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 60nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50072147BDBM50072147(CHEMBL100473 | 2,3-Bis-[1-amino-1-(2-amino-phenyls...)
Affinity DataIC50: 60nMAssay Description:Inhibition of the dual specificity kinase MEK-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Rat)
University of Gothenburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50498024BDBM50498024(CHEMBL3326332)
Affinity DataIC50: 73nMAssay Description:Inhibition of MEK1/2 in rat IEC6 cells assessed as reduction in ERK1/2 loop phosphorylation dosed 30 mins before to stimulation with 10% serum for 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50136226BDBM50136226(CHEMBL3753341)
Affinity DataIC50: 82nMAssay Description:Inhibition of recombinant human MEK2 by radiometric assay in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 104963BDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataKd:  100nMAssay Description:Binding affinity to MEK2 (unknown origin) incubated for 1 hr by qPCR based KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  110nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  110nMAssay Description:Binding affinity to MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  110nMAssay Description:Binding constant for full-length MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4814BDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  110nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 104963BDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant full length human His-tagged MEK2 expressed in baculovirus expression system using ERK K52R dead variant as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  120nMAssay Description:Binding constant for full-length MEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  120nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31095BDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  120nMAssay Description:Binding constant for MEK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802681BDBM802681(US20260109708, Example 45)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802682BDBM802682(US20260109708, Example 46)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802683BDBM802683(US20260109708, Example 47)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802684BDBM802684(US20260109708, Example 48)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802685BDBM802685(US20260109708, Example 49)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802686BDBM802686(US20260109708, Example 50)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802687BDBM802687(US20260109708, Example 51)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802688BDBM802688(US20260109708, Example 52)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802673BDBM802673(US20260109708, Example 37)
Affinity DataIC50: 150nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2026
Entry Details
US Patent

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