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Report error Found 805 Enz. Inhib. hit(s) with Target = 'Dual specificity protein kinase CLK3'
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50469189(CHEMBL4284209)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to CLK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50589394(CHEMBL4797564)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human CLK3 administered orallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50238867(CHEMBL4083249)
Affinity DataIC50: 8nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 9.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50466825(CHEMBL4290222)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50627525(CHEMBL5441121)
Affinity DataIC50: 10nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM12621(2,4-Diamino-5-ketopyrimidine 39 | 5-[(2,3-difluoro...)
Affinity DataKd:  13nMAssay Description:Binding constant for CLK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
LigandPNGBDBM50639252(CHEMBL5560595)
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CLK3 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 22nMAssay Description:Inhibition of CLK3 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM50627523(CHEMBL5438728)
Affinity DataIC50: 23nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50609263(CHEMBL4796016)
Affinity DataIC50: 28nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM6878(5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human CLK3 (275 to 632 residues) expressed in Escherichia coli BL21(DE3) preincubated for 10 mins followed by substrate addition by pyr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50627526(CHEMBL5439276)
Affinity DataIC50: 30nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 142 | US10106527, Compound 14...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50627509(CHEMBL5430262)
Affinity DataIC50: 38nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50645374(CHEMBL5574295)
Affinity DataIC50: 39nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human CLK3-4 (275 to 632 residues) expressed in Escherichia coli BL21 (DE3) Turner using S6-peptide as substrate incubated for 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant CLK3 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human CLK3 in presence of ATP at Km concentration by radiometric filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50589392(Lorecivivint | Adavivint | Sm04690 | SM-04690 | SM...)
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50627439(CHEMBL5408907)
Affinity DataIC50: 49nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50627440(CHEMBL5427842)
Affinity DataIC50: 53nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50627446(CHEMBL5436754)
Affinity DataIC50: 73nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50589392(Lorecivivint | Adavivint | Sm04690 | SM-04690 | SM...)
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant human GST-tagged CLK3 expressed in baculovirus expression system by lantha screen kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2017
Entry Details Article
PubMed
LigandPNGBDBM50627490(CHEMBL5422486)
Affinity DataIC50: 90nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50613085(CHEMBL5081787)
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50627420(CHEMBL5396550)
Affinity DataIC50: 96nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50097867(CHEMBL3589660)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM50639249(CHEMBL5564232)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639248(CHEMBL5568383)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639245(CHEMBL5555969)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639242(CHEMBL5559924)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639255(CHEMBL5567834)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639254(CHEMBL5559906)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639253(CHEMBL5558849)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639259(CHEMBL5563432)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639258(CHEMBL5287080)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639256(CHEMBL5566340)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639265(CHEMBL5561941)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639264(CHEMBL5559654)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50639260(CHEMBL5565284)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50627575(CHEMBL5405233)
Affinity DataIC50: 107nMAssay Description:Inhibition of human full length CLK3 (1 to 490 residues) expressed in Sf9 cells using S6 peptide and [gamma33P]ATP as substrate incubated for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetDual specificity protein kinase CLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50: 110nMAssay Description:Inhibition of human CLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
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