Compile Data Set for Download or QSAR
Report error Found 2385 Enz. Inhib. hit(s) with Target = 'Endothelin receptor type B'
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50155245(CHEMBL3774897)
Affinity DataIC50: 0.00600nMAssay Description:Displacement of [125I]Endothelin-1 from human recombinant Endothelin-B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50208985(CHEMBL3885244)
Affinity DataIC50: 0.00600nMAssay Description:Displacement of [125I]endothelin-1 from human recombinant ETB receptor expressed in CHO cells measured after 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataKi:  0.00800nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataKi:  0.0100nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368606(Sarafotoxin S6B)
Affinity DataKi:  0.0120nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368606(Sarafotoxin S6B)
Affinity DataKi:  0.0130nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataKi:  0.0150nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368605(CHEMBL1790178)
Affinity DataKi:  0.0160nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368607(CHEMBL1790180)
Affinity DataKi:  0.0210nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368605(CHEMBL1790178)
Affinity DataKi:  0.0230nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368607(CHEMBL1790180)
Affinity DataKi:  0.0360nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the rat hippocampusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50287890(Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-lle-lle-Tr...)
Affinity DataKi:  0.0770nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043326(c(Cys-Ser-Cys)-Ser-Ser-Leu-Met-Asp-Lys-Gln-c(Cys-V...)
Affinity DataIC50: 0.0930nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50143784(J-104132 | CHEMBL305576 | (5S,6R,7R)-5-Benzo[1,3]d...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2012
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50197953(CHEMBL3980643)
Affinity DataIC50: 0.100nMAssay Description:Agonist activity at human recombinant ETB receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataIC50: 0.120nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071445(N-[(R)-1-[(S)-2-Ethenesulfonylamino-1-(1H-indol-3-...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.140nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043322(c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp-Lys-Gln-Cys)-V...)
Affinity DataIC50: 0.170nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368776(CHEMBL1790962)
Affinity DataIC50: 0.170nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataIC50: 0.200nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.200nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.200nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061078((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.200nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50395673(CHEMBL2165327)
Affinity DataIC50: 0.208nMAssay Description:Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071438((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071435((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071437(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-(pro...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071423(N-[(R)-1-[(S)-2-(2-Ethoxy-ethanesulfonylamino)-1-(...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50289647(Compound RES-701-1(1-10)/[A15]ET-1 | CHEMBL263855)
Affinity DataIC50: 0.240nMAssay Description:Binding activity to ET-B receptor on bovine cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071420(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-(pro...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071436(N-[(R)-1-[(S)-2-(Butane-1-sulfonylamino)-1-(1H-ind...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50287885(Suc-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Gly-lle-lle-Tr...)
Affinity DataKi:  0.25nMAssay Description:Ability to inhibit [125I]ET-3 binding to the Endothelin B receptor from porcine lung membranes was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368772(CHEMBL2373291)
Affinity DataIC50: 0.25nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061074((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.280nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.320nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.320nMAssay Description:Ability to displace endothelin ([125I]ET-3) from endothelin B receptor derived from cerebellar tissue of porcine.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368774(CHEMBL1790963)
Affinity DataIC50: 0.330nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071421(N-[(R)-1-[(S)-2-Benzenesulfonylamino-1-(1H-indol-3...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071439(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-(pro...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071430(N-[(R)-1-[(S)-2-Ethanesulfonylamino-1-(1H-indol-3-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071428(N-[(R)-1-{(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-[((E...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50197955(CHEMBL1515091)
Affinity DataIC50: 0.410nMAssay Description:Antagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368777(CHEMBL2373292)
Affinity DataIC50: 0.420nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Bovine)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043324(c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp-Lys-Gln-Cys)-V...)
Affinity DataIC50: 0.450nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.470nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061085((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.480nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071444(N-[(R)-1-[1-(Butane-1-sulfonylaminocarbonyl)-3-met...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071443(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-phen...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071440(N-[(R)-1-[2-(Butane-1-sulfonylamino)-1-naphthalen-...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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